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Discussion on Layout and Use of Buffer Tanks

Buffer tanks are used in most pharmaceutical production processes, so how to lay out the buffer tanks to achieve a better use effect? Here are some of my views, and welcome everyone to discuss and exchange.

1. Selection of the size of the buffer tank

The size of the buffer tank is generally selected according to the size of the filling capacity, and should not be too large, generally 3L-5L is suitable. For large volume filling, a relatively large buffer tank will be better choice. For the case where there is no liquid replenishment and only one-time liquid addition, the size of the buffer tank should be selected according to the production requirements. There are several reasons why the buffer tank cannot be too large. The first is that the large buffer tank can only be cleaned and sterilized in-line, because it is too large to be easy to move; another reason is that a large buffer tank will also make the liquid level change relatively large, which will easily affect the filling accuracy.

2. The location layout of the buffer tank

First of all, theoretically, the buffer tank should be deployed under A-level laminar flow protection;

Secondly, the buffer tank should be relatively close to the terminal filling position, so as to reduce the residue in the pipeline and reduce the waste of liquid medicine;

Thirdly, the lowest point liquid outlet of the buffer tank should be slightly higher than the liquid inlet of the liquid separator, so that the liquid in the buffer tank can flow to the liquid separator by itself, reducing the liquid residue in the pipeline;

Lastly, the highest liquid level of the buffer tank is recommended to be lower than the liquid outlet of the filling needle to prevent the liquid from flowing out of the filling needle due to equipment malfunction.

3.Liquid level control of the buffer tank

There are generally two ways to control the liquid level of the buffer tank, one is the way of high and low liquid level gauge, and the other is the way of in-line weighing.

The high and low liquid level gauge control liquid level generally has a relatively large liquid level difference. The distance of the liquid level difference is the distance of the high and low liquid level gauge, and this can affect the filling accuracy. Now the improved liquid level gauge control method is to only use the low liquid level gauge. Replenish when the low liquid level gauge is off, and stop refilling when the high liquid level gauge is on. It is equivalent to increasing the frequency of refilling, but reducing the liquid level gap, making the filling accuracy more stable.

Weighing system controls the liquid level because the replenishment parameters can be set freely, so that, the liquid level can be controlled at a relatively stable liquid level, so that the filling accuracy is more stable.

Generally speaking, the liquid level of the buffer tank is generally controlled at one-third of the total capacity, not more than half, which has two advantages, one is to reduce the liquid level difference of the last remained liquid to improve filling accuracy. The other is to prevent non-stop refilling caused by control system failure, and to leave enough space for malfunction, so that people have the reaction time to deal with faults.

4 Selection of the exhalation valve on the buffer tank

Generally, a breathing valve needs to be installed on the buffer tank to ensure that the relative pressure in the buffer tank is 0, except for special requirements, such as the need to maintain positive pressure in the liquid buffer tank that needs to be filled with nitrogen.

The breathing speed of the breathing valve is required to be slightly higher than the refilling speed to ensure that there will be no pressure fluctuations in the buffer tank. The general requirement is that the breathing flow rate≧buffer tank refilling flow rate≧filling rate.

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